The research analyzes the process of formation of the ethics committee as a new institution in the system of regulation of genetic research. The external factors of this process are the increasing digitalization of medical and research practices, as well as the special situation that is developing in the field of genomic research and the use of genetic technologies, where issues of philosophy, jurisprudence and administration have generated many fundamentally new, and sometimes unexpected contexts. The author shows the similarity and (...) difference of approaches to the inclusion of the ethics committee in the national regulatory systems of different countries and determines the prospects for further integration of the new institution into normative and administrative-regulatory and law enforcement practices. The research applies all the main methods of system analysis and structural and functional analysis, as well as the comparative legal method. At the stage of generalization of empirical material, the author turns to the means and methods of philosophical phenomenology and phenomenological sociology. The study revealed that the ethics committee may have different institutional and regulatory functions in a variety of management and legal systems. Being hybrid in nature, the ethics committee performs various functions, and in various state legal systems and traditions it can combine elements of legislative, executive and judicial power. At times, the ethics committee may go beyond the scope of both a purely administrative and exclusively legal regulator. All this indicates that the integration of this institution into the legal system and into a variety of social practices is far from being completed. (shrink)

The problem of commensurability/incommensurability of different cultural codes is a key problem of modern civilizational development. This is the problem of the search for communicative unity in the world of cultural and biological diversity, which has to be protected, and the search for the cohesion of different Umwelten, of semiotically-defined artificial and natural environments, of ecological and cognitive niches, taking into account that each of them has their own identity and uniqueness. The purpose of the article is to draw attention (...) to the fact that the question of the so-called incommensurability of different conceptual schemes, paradigms, language consciousnesses is widely discussed not only in cross-cultural studies and philosophical problems of translation but also in connection with the problems of incommensurability between the language of classical physics and the language of relativistic quantum physics. Attention is drawn to the problem of the incommensurability and correlation of different languages that are used in debates about the foundations of quantum mechanics, its interpretation, comprehension and ontology. Two approaches stand out in this debate. The first approach is based on the language of the formed being, on the language of things localized in time and on the logic of Aristotle. The second approach is based on the language of the becoming, process and nonlocality, on the search for various processual-oriented temporal logics. In this regard, we discuss the processual approach to understanding quantum mechanics, proposed in the philosophical and physical works of D. Bohm. The authors argue that the experience of constructive understanding of the metaproblems of the interpretation of quantum mechanics, the critical reception of the legacy of such philosophers of the process as Peirce, Bergson and Whitehead, the deep reflection on the problems of commensurability/ incommensurability of linguistic consciousnesses of different cultures – will eventually create a common synergetic-interdisciplinary space of cooperation for the solutions of the above-mentioned issues. (shrink)

This article examines the metaphysics of Lev Platonovich Karsavin, which absorbed the specific features of the life of this Russian theologian, philosopher, scholar, and poet and his lo...

In the Renaissance period, being a “humanist” meant graduating from a philosophical faculty and teaching the collection of disciplines necessary to become a university student. In this view, the humanist is the man of the unaccomplished higher education, or, a school teacher. Neither his status, nor the status of the disciplines he taught was high. Over time the situation changed. Studying ancient languages opened a whole world of the disappeared civilization, obvious ancestors to the Renaissance; a conception of humanitarian-historical cognition (...) was founded. The Renaissance was the first to formulate a problem of comprehension—of the historical epochs passed, of the texts based on other experience and different mentality. In the context of unique singularitythe concepts of fate and biography were overestimated. The thesis of micro and macrocosm unity was revived. The humanists have created a new translation of the Holy Writ; as a result, the sense of many rite ceremonies of liturgy became clearer. Historicism and criticism have brought a new type of thinking and a new system of values in the long run. Humanistic values constructed the first system that had no need in religious foundation, and its relation with Christianity was not logical, but historical.All this, though well known, gains quite other sense today. The world becomes more and more complicated and multicultural. A post-secular, polio-confessional socium comes to replace the secular society. The former needs a new experience, as unique as that of Renaissance humanitarians. (shrink)

The aim of this article is to compare two models of reality construction and their applicability to explain the various effects of the digitalization process. The evolution of the constructivist ideas about reality is reconstructed in the context of the dispute among realists and constructivists, which was one of the most significant events in the epistemology and philosophy of science of the 20th century. The author points out the differences between the intellectual and the social construction of reality, and carries (...) out a comparative analysis of the philosophical theories and concepts describing the aforementioned alternatives. The intellectual construction of reality, which often takes place in theoretical physics at different stages of its development, is also analyzed. Particular consideration is given to the philosophic-scientific contexts generated by the sociology of knowledge, the theory of speech acts, and the actor-network theory. The article also shows a distinction between the construction and the constitution of reality. The constitution of reality within various types of non-theoretical thinking, fixed using the means and methods of phenomenological philosophy of science, allows identifying and describing the main contexts through which the word reality acquires significance and is endowed with meaning in the present-day intellectual and social practices. Special attention is paid to the concepts of virtual reality and digital reality. The features of the intellectual construction of virtual reality are described. The difference between the intellectual and the social construction of digital reality is substantiated as between two alternative practices, which determine the meaning, and the prospects of digitalization. This distinction may be of particular interest to those who design digital platforms and implement digitalization in various areas of human life and society, especially in as education, legal procedure, management, economics, and business. Today, when partly spontaneous, partly controlled digitalization is taking place in these spheres, the results of this study make it possible not only to understand the logic of the changes taking place but also to apply forecasting and planning methods actively, i.e., constructing the digital reality. (shrink)

Among the two rival views on the outside world, preference was historically given to the substantial point of view. The success of Aristotle’s logic was due to the simple substantial ontology built by him. In that logic, the subject is characterized by an instant set of properties. The change of objects leads to the change of properties. The reduction of processes to substances causes a number of problems. The construction of procedural logic should be started with the construction of the (...) most abstract procedural ontology. The main difference of processes from substances is their extension. Each item, as a process, can be considered as a bundle of parallel processes. The relation the individual S has the property P is the main relation in the substantial ontology. In the procedural ontology, one of the main ones is the relation process R is a sub-process of the process Q. This relation is sufficient for the interpretation of the main syllogistic constants. As a result, we get Łukasiewicz syllogistic for reasoning about parallel processes. The extension of the processes allows us to talk about their parts. The second main relation of procedural ontology is the relation process P consists of two successive processes Q and R. If the processes Q and R are successive, it is natural to make use of the relation earlier-later. In procedural ontology, time does not emerge through external postulation but exists within it. In the ontology of processes, one can naturally define the concept of causality, which becomes a logical concept. However, the success of the procedural view of the outside world is only possible if the new ways of reasoning prove to be a more effective tool for intellectual cognitive activity than the existing ones. (shrink)

We begin by presenting William of Ockham's various formulations of his principle of parsimony, Ockham's Razor. We then define a reaction mechanism and tell a personal story of how Ockham's Razor entered the study of one such mechanism. A small history of methodologies related to Ockham's Razor, least action and least motion, follows. This is all done in the context of the chemical (and scientific) community's almost unthinking acceptance of the principle as heuristically valuable. Which is not matched, to put (...) it mildly, by current philosophical attitudes toward Ockham's Razor. What ensues is a dialogue, pro and con. We first present a context for questioning, within chemistry, the fundamental assumption that underlies Ockham's Razor, namely that the world is simple. Then we argue that in more than one pragmatic way the Razor proves useful, without at all assuming a simple world. Ockham's Razor is an instruction in an operating manual, not a world view. Continuing the argument, we look at the multiplicity and continuity of concerted reaction mechanisms, and at principal component and Bayesian analysis (two ways in which Ockham's Razor is embedded into modern statistics). The dangers to the chemical imagination from a rigid adherence to an Ockham's Razor perspective, and the benefits of the use of this venerable and practical principle are given, we hope, their due. (shrink)

The dynamical equations of quantum mechanics are rewritten in the form of dynamical equations for the measurable, positive marginal distribution of the shifted, rotated, and squeezed quadrature introduced in the so-called “symplectic tomography”. Then the possibility of a purely classical description of a quantum system as well as a reinterpretation of the quantum measurement theory is discussed and a comparison with the well-known quasi-probabilities approach is given. Furthermore, an analysis of the properties of this marginal distribution, which contains all the (...) quantum information, is performed in the framework of classical probability theory. Finally, examples of the harmonic oscillator's states dynamics are treated. (shrink)

It is usually believed that a picture of Quantum Mechanics in terms of true probabilities cannot be given due to the uncertainty relations. Here we discuss a tomographic approach to quantum states that leads to a probability representation of quantum states. This can be regarded as a classical-like formulation of quantum mechanics which avoids the counterintuitive concepts of wave function and density operator. The relevant concepts of quantum mechanics are then reconsidered and the epistemological implications of such approach discussed.

RESUMO No artigo, apresenta-se um panorama da vida e da obra do professor, filólogo e cientista russo N. Vassíliev, com ênfase em sua contribuição para os estudos bakhtinianos internacionais. A longa convivência e parceria dos autores com N. Vassíliev permite-lhes não só desenhar o perfil de um pesquisador sério das humanidades, mas também mostrar seu mundo de paixões pessoais e o papel de sua biografia na escolha do núcleo de suas pesquisas científicas: a problemática dos estudos bakhtinianos. Dedica-se atenção especial (...) às soluções propostas por ele ao problema dos textos disputados. ABSTRACT The article presents an overview of the life and works of the Russian scholar, philologist Professor Nikolay Vasiliev and the assessment of his contribution to international Bakhtin studies. For many years the authors have communicated and cooperated with N. Vasiliev during the long years that give them the opportunity not only to create a portrait of this serious researcher, but also to show the world his hobbies, how his biography influenced on the choice of the issue of Bakhtin studies as a central topic for his research. Special attention is paid to his proposed solutions to the problem of disputed texts. (shrink)

The notion of conditional entropy is extended to noncomposite systems. The \-deformed entropic inequalities, which usually are associated with correlations of the subsystem degrees of freedom in bipartite systems, are found for the noncomposite systems. New entropic inequalities for quantum tomograms of qudit states including the single qudit states are obtained. The Araki–Lieb inequality is found for systems without subsystems.

The mechanical properties of vertebrate cells are largely defined by the system of intermediate filaments (IF). As part of a dense network, IF polymers are constantly rearranged and relocalized in the cell to fulfill their duty as cells change shape, migrate, or divide. With the development of new imaging technologies, such as photoconvertible proteins and super‐resolution microscopy, a new appreciation for the complexity of IF dynamics has emerged. This review highlights new findings about the transport of IF, the remodeling of (...) filaments by a process of severing and re‐annealing, and the subunit exchange that occurs between filament precursors and a soluble pool of IF. We will also discuss the unique dynamic features of the keratin IF network. Finally, we will speculate about how the dynamic properties of IF are related to their functions. (shrink)

The content-analysis of the Russian federal and regional basic legislation on the cultural policy has indicated a need in a deep revision of all existing regulatory legal acts, which support the state cultural policy implementation towards building a universal terminology and vesting the functions on the cultural policy implementation in the government as opposed to the statement of the departmental specific approach to the culture.

The paper explores the role of the media in influencing public opinion from an inferential-pragmatic perspective. It presents preliminary results of the study focused on representation of Russia in Western newspapers. Drawing on Critical Discourse Analysis (Fairclough 1995,2001; van Dijk 2009) and media linguistics (Fowler 1991, Richardson 2007, among others) the study centres around the linguistic means of construing ambiguity/uncertainty, viewed as a strategy of persuasion. We mostly focus on the semantics of certain groups of words and other textual features (...) such as indefinite pronouns, epistemic modality, passive voice, present perfect tense, interrogative headlines and some other tools used in media texts to construe ambiguity which, in its turn, arguably aims at influencing public opinion. We also look at presupposition, information structure, evaluation and transitivity. Though we have limited our study to the English language sources (The Guardian, The Telegraph, The Independent, The Washington Post, The Wall Street Journal, the Chicago Tribune, news websites of the BBC, Reuters, Express, Politico and Fox News, among others), we are not suggesting that linguistic ambiguity is a feature of Western, rather than Russian, or other languages' media. (shrink)

Tomographic approach to describing both the states in classical statistical mechanics and the states in quantum mechanics using the fair probability distributions is reviewed. The entropy associated with the probability distribution (tomographic entropy) for classical and quantum systems is studied. The experimental possibility to check the inequalities like the position–momentum uncertainty relations and entropic uncertainty relations are considered.

The cross-cultural study of the words defining social values are of particular importance in interdisciplinary contexts, as the knowledge of their culture-specific semantic as well as discursive characteristics contributes to a better understanding of how people think and act in a society. The paper focuses on the English lexeme tolerance and its translation equivalents in Russian and Serbian. It aims to specify linguacultural characterizations of the notion of tolerance in British, Russian and Serbian cultures. The data were taken from dictionaries, (...) British National Corpus (BNC), Russian National Corpus (RNC), Corpus of Contemporary Serbian (SrpKor), as well as media and Internet resources. The combined methodology (pragma-semantic, discourse and lingua-cultural analysis) enabled us to reveal that the dictionary equivalents of the English lexeme tolerance are not complete, but partial. The findings show that in Russian and Serbian the words of Latin etymology tolerantnost’ and tolerancija seem to invoke both positive and negative attitudes, reflecting cultural norms and values. The paper contributes to the understanding of tolerance in the observed linguacultures and confirms that it is important to consider interdisciplinary approaches to language studies. (shrink)

This paper continues the analysis of the advantages and disadvantages of ontic structural realism, which begun in the first part of the paper. Non-eliminative versions of this approach are considered, which try to find a compromise between the ontology of structures and the ontology of objects. It is shown that the semirealism of A. Chakravartti and the constructive structural realism of T. Cao have a number of limitations caused by the authors’ desire to strictly distinguish between the nature of the (...) existence of objects and structures. Then the version of the relationship between structures and entities is presented. Firstly, two concepts are divided according to their content: “object” and “entity”. Second, to solve the problem of causality, I suggest that the nature of entities and structures lie in their ability to act. It is this ability that I propose to use instead of the popular concepts of “causal powers”, “causal properties” or “dispositions”. Third, instead of a rigid alternative to ontological primitives – either essence, or causal relations, or structures – the concept of ontological pluralism and inherited existence is proposed. There each entity is represented as a derivative of another structure and, in turn, creates other entities and structures. Thus, both structures and entities at each level of the complexity hierarchy partially inherit the ability to act and a certain degree of existence from the structures and entities of the previous levels. Finally, I am trying to clarify the modal aspects of the ontic structural realism. Following the popular interpretations of quantum theory, the ability to act, and hence the existence of structures and entities, are considered separately in two worlds – potential and actual ones. The potential world is associated with a set of possible objects and structures of quantum theory, and the actual world is associated with a set of real (observable) objects and structures of classical physical theories. The transition from the potential to the actual world is proposed to be considered as a primitive metaphysical event. The proposed concept partially overcomes the objections to ontic structural realism, thereby strengthening its position in the discussion about the reality of quantum objects. (shrink)

The article refutes the widespread view that Dostoevsky's Christian beliefs were strictly Orthodox. It is proved that Dostoevsky's religious and philosophical searches' central tendency is the criticism of historical, ecclesiastical Christianity as a false, distorted form of the teaching of Jesus Christ and the desire to restore this teaching in its original purity. Modern researchers of the history of early Christianity find more and more arguments in favor of the fact that the actual teaching of Jesus Christ is contained in (...) that religious movement, which the church called the Gnostic heresy. The exact philosophical expression of the teaching of Christ was received in the later works of J.G. Fichte, whose ideas had a strong influence on the Russian writer. Like Fichte, Dostoevsky understands Christ as the first person who showed the possibility of revealing God in himself and gaining divine omnipotence and eternal life directly in earthly reality. In this sense, every person can become like Christ. Dostoevsky's main characters walk the path of Christ and show how difficult this path is. The article shows that Dostoevsky used in his work not only the philosophical version of true Christianity developed by German philosophy, but also the key motives of the Gnostic myth, primarily the idea that our world, filled with evil and suffering, is created not by the supreme, good God-Father, but by the evil Demiurge, the Devil. (shrink)

We have synthesized a 582,970-base pair Mycoplasma genitalium genome. This synthetic genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type M. genitalium G37 except MG408, which was disrupted by an antibiotic marker to block pathogenicity and to allow for selection. To identify the genome as synthetic, we inserted "watermarks" at intergenic sites known to tolerate transposon insertions. Overlapping "cassettes" of 5 to 7 kilobases (kb), assembled from chemically synthesized oligonucleotides, were joined by in vitro recombination to produce intermediate (...) assemblies of approximately 24 kb, 72 kb ("1/8 genome"), and 144 kb ("1/4 genome"), which were all cloned as bacterial artificial chromosomes in Escherichia coli. Most of these intermediate clones were sequenced, and clones of all four 1/4 genomes with the correct sequence were identified. The complete synthetic genome was assembled by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae, then isolated and sequenced. A clone with the correct sequence was identified. The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments. 10.1126/science.1151721. (shrink)

This article defends the view that liars need not intend to deceive. I present common objections to this view in detail and then propose a case of a liar who can lie but who cannot deceive in any relevant sense. I then modify this case to get a situation in which this person lies intending to tell his hearer the truth and he does this by way of getting the hearer to recognize his intention to tell the truth by lying. (...) This case, and further cases that I develop from it, demonstrate that lying without the intention to deceive is possible. (shrink)

In their paper published in 2017 in Philosophical Psychology, Ronja Rutschmann and Alex Wiegmann introduce a novel kind of lies, the indifferent lies. According to them, these lies are not intended to deceive simply because the liars do not care whether their audience is going to believe them or not. It seems as if indifferent lies avoid the objections raised against other kinds of lies supposedly not intended to deceive. I argue that this is not correct. Indifferent lies, too, are (...) either intended to deceive or are not lies at all, since they do not involve genuine assertions. (shrink)